|Other Names||Parkin coregulated gene protein, Molecular chaperone/chaperonin-binding protein, PARK2 coregulated gene protein, PACRG, GLUP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.|
|Tissue Location||Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas Expressed in primary Schwann cells and very weakly by monocyte- derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients.|
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This gene encodes a protein that is conserved acrossmetazoans. In vertebrates, this gene is linked in a head-to-headarrangement with the adjacent parkin gene, which is associated withautosomal recessive juvenile Parkinson's disease. These genes areco-regulated in various tissues and they share a bi-directionalpromoter. Both genes are associated with susceptibility to leprosy.The parkin co-regulated gene protein forms a large molecularcomplex with chaperones, including heat shock proteins 70 and 90,and chaperonin components. This protein is also a component of Lewybodies in Parkinson's disease patients, and it suppresses unfoldedPael receptor-induced neuronal cell death. Multiple transcriptvariants encoding different isoforms have been found for this gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Wilson, G.R., et al. Fertil. Steril. 93(7):2262-2268(2010)Dagda, R.K., et al. J. Bioenerg. Biomembr. 41(6):473-479(2009)Velez, D.R., et al. Int. J. Tuberc. Lung Dis. 13(9):1068-1076(2009)Taylor, J.M., et al. Parkinsonism Relat. Disord. 15(6):417-421(2009)
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