|Other Names||Transcription initiation factor IIA subunit 1, General transcription factor IIA subunit 1, TFIIAL, Transcription initiation factor TFIIA 42 kDa subunit, TFIIA-42, Transcription initiation factor IIA alpha chain, TFIIA p35 subunit, Transcription initiation factor IIA beta chain, TFIIA p19 subunit, GTF2A1, TF2A1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.|
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Provided below are standard protocols that you may find useful for product applications.
Accurate transcription initiation on TATA-containing classII genes involves the ordered assembly of RNA polymerase II(POLR2A; MIM 180660) and several general initiation factors(summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One ofthese factors is TFIIA, which when purified from HeLa extractsconsists of 35-, 19-, and 12-kD subunits.
Huang, Y.W., et al. Oncol. Rep. 22(4):853-861(2009)Vega, A., et al. Gynecol. Oncol. 112(1):210-214(2009)Hieb, A.R., et al. J. Mol. Biol. 372(3):619-632(2007)Lee, K.A., et al. Cytokine 38(2):96-100(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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