DNAJC5 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H3Z4 |
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Clone Names | 100712091 |
Gene ID | 80331 |
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Other Names | DnaJ homolog subfamily C member 5, Cysteine string protein, CSP, DNAJC5, CSP |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DNAJC5 (HGNC:16235) |
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Function | Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity). |
Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q29455}. Membrane {ECO:0000250|UniProtKB:Q29455}; Lipid-anchor {ECO:0000250|UniProtKB:Q29455}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:Q29455}. Melanosome. Cell membrane. Note=The association with membranes is regulated by palmitoylation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000250|UniProtKB:Q29455, ECO:0000269|PubMed:17081065} |
Tissue Location | Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the J protein family. J proteinsfunction in many cellular processes by regulating the ATPaseactivity of 70 kDa heat shock proteins. The encoded protein plays arole in membrane trafficking and protein folding, and has beenshown to have anti-neurodegenerative properties. The encodedprotein is known to play a role in cystic fibrosis and Huntington'sdisease. A pseudogene of this gene is located on the short arm ofchromosome 8.
References
Johnson, J.N., et al. Biochem. Cell Biol. 88(2):157-165(2010)Schmidt, B.Z., et al. J. Biol. Chem. 284(7):4168-4178(2009)Greaves, J., et al. J. Biol. Chem. 283(36):25014-25026(2008)Park, J., et al. Am. J. Respir. Cell Mol. Biol. 39(1):68-76(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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