|Other Names||Vacuolar protein sorting-associated protein 37C, hVps37C, ESCRT-I complex subunit VPS37C, VPS37C, PML39|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|
|Cellular Location||Late endosome membrane; Peripheral membrane protein. Note=Probably associates with membranes. Recruited to the plasma membrane by HIV-1|
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Provided below are standard protocols that you may find useful for product applications.
VPS37C is a subunit of ESCRT-I (endosomal sorting complexrequired for transport I), a complex in the class E vacuolarprotein sorting (VPS) pathway required for sorting ubiquitinatedtransmembrane proteins into internal vesicles of multivesicularbodies (Eastman et al., 2005 [PubMed 15509564]).
Rose, J. Phd, et al. Mol. Med. (2010) In press :Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Eastman, S.W., et al. J. Biol. Chem. 280(1):628-636(2005)
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