|Other Names||Tonsoku-like protein, Inhibitor of kappa B-related protein, I-kappa-B-related protein, IkappaBR, NF-kappa-B inhibitor-like protein 2, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2, TONSL, IKBR, NFKBIL2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.|
|Cellular Location||Cytoplasm. Nucleus. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks|
|Tissue Location||Expressed in heart, skeletal muscle and tracheal epithelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is thought to be anegative regulator of NF-kappa-B mediated transcription. Theencoded protein may bind NF-kappa-B complexes and trap them in thecytoplasm, preventing them from entering the nucleus andinteracting with the DNA. Phosphorylation of this protein targetsit for degradation by the ubiquitination pathway, which frees theNF-kappa-B complexes to enter the nucleus.
Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Norman, D.A., et al. Ann. Hum. Genet. 64 (PT 1), 15-23 (2000) :Ray, P., et al. J. Biol. Chem. 270(18):10680-10685(1995)
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