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NFKBIL2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96HA7 |
|---|---|
| Clone Names | 110808196 |
| Gene ID | 4796 |
|---|---|
| Other Names | Tonsoku-like protein, Inhibitor of kappa B-related protein, I-kappa-B-related protein, IkappaBR, NF-kappa-B inhibitor-like protein 2, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2, TONSL, IKBR, NFKBIL2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TONSL {ECO:0000303|PubMed:21055983, ECO:0000312|HGNC:HGNC:7801} |
|---|---|
| Function | Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:21113133, PubMed:26527279, PubMed:27797818, PubMed:29478807, PubMed:27338793, PubMed:30773278). The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication (PubMed:21055983, PubMed:21055984, PubMed:21055985). It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:27797818, PubMed:29478807). Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination (PubMed:27797818, PubMed:29478807). Within the complex, TONSL acts as a histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones (PubMed:29478807, PubMed:27338793). Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3.1 (PubMed:27338793). |
| Cellular Location | Nucleus. Chromosome. Cytoplasm Note=Mainly nuclear (PubMed:21055983, PubMed:21055984). Localizes to DNA damage sites, accumulates at stressed replication forks (PubMed:21055983, PubMed:21055984, PubMed:26527279, PubMed:27338793) Recruited to stalled or collapsed replication forks following histone replacement by histone chaperones ASF1A and the CAF-1 complex: TONSL acts as a histone reader that recognizes and binds newly synthesized histones (PubMed:29478807). |
| Tissue Location | Expressed in heart, skeletal muscle and tracheal epithelial cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is thought to be anegative regulator of NF-kappa-B mediated transcription. Theencoded protein may bind NF-kappa-B complexes and trap them in thecytoplasm, preventing them from entering the nucleus andinteracting with the DNA. Phosphorylation of this protein targetsit for degradation by the ubiquitination pathway, which frees theNF-kappa-B complexes to enter the nucleus.
References
Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Norman, D.A., et al. Ann. Hum. Genet. 64 (PT 1), 15-23 (2000) :Ray, P., et al. J. Biol. Chem. 270(18):10680-10685(1995)
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