|Other Names||Tonsoku-like protein, Inhibitor of kappa B-related protein, I-kappa-B-related protein, IkappaBR, NF-kappa-B inhibitor-like protein 2, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2, TONSL, IKBR, NFKBIL2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.|
|Cellular Location||Cytoplasm. Nucleus. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks|
|Tissue Location||Expressed in heart, skeletal muscle and tracheal epithelial cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is thought to be anegative regulator of NF-kappa-B mediated transcription. Theencoded protein may bind NF-kappa-B complexes and trap them in thecytoplasm, preventing them from entering the nucleus andinteracting with the DNA. Phosphorylation of this protein targetsit for degradation by the ubiquitination pathway, which frees theNF-kappa-B complexes to enter the nucleus.
Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Norman, D.A., et al. Ann. Hum. Genet. 64 (PT 1), 15-23 (2000) :Ray, P., et al. J. Biol. Chem. 270(18):10680-10685(1995)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.