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ERN1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O75460
Clone Names 70319131
Peptide ID 70319131
Additional Information
Gene ID 2081
Other Names Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, hIRE1p, Ire1-alpha, IRE1a, Serine/threonine-protein kinase, Endoribonuclease, 3126-, ERN1 (HGNC:3449)
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERN1 (HGNC:3449)
Function Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Cellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein
Tissue Location Ubiquitously expressed. High levels observed in pancreatic tissue.
Research Areas
Citations (0)

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The protein encoded by this gene is the ER to nucleussignalling 1 protein, a human homologue of the yeast Ire1 geneproduct. This protein possesses intrinsic kinase activity and anendoribonuclease activity and it is important in altering geneexpression as a response to endoplasmic reticulum-based stresssignals.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Li, H., et al. Proc. Natl. Acad. Sci. U.S.A. 107(37):16113-16118(2010)Auf, G., et al. Proc. Natl. Acad. Sci. U.S.A. 107(35):15553-15558(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Gupta, S., et al. PLoS Biol. 8 (7), E1000410 (2010) :

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$ 80.00
Cat# BP17747b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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