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UAP1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q16222 |
|---|---|
| Clone Names | 101008202 |
| Gene ID | 6675 |
|---|---|
| Other Names | UDP-N-acetylhexosamine pyrophosphorylase, Antigen X, AGX, Sperm-associated antigen 2, UDP-N-acetylgalactosamine pyrophosphorylase, AGX-1, UDP-N-acetylglucosamine pyrophosphorylase, AGX-2, UAP1, SPAG2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | UAP1 {ECO:0000303|PubMed:9603950, ECO:0000312|HGNC:HGNC:12457} |
|---|---|
| Function | Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide (PubMed:9603950, PubMed:9765219). Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) (PubMed:9765219). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses (PubMed:36603579). |
| Cellular Location | Cytoplasm, cytosol. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail. |
| Tissue Location | Widely expressed (PubMed:8025165). Expressed at low level in placenta, muscle and liver (PubMed:8025165) [Isoform AGX2]: Isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
UAP1 converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.
References
Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Peneff, C., et al. EMBO J. 20(22):6191-6202(2001)Wang-Gillam, A., et al. J. Biol. Chem. 273(42):27055-27057(1998)Diekman, A.B., et al. Mol. Reprod. Dev. 50(3):284-293(1998)
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