TBR1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q16650 |
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Clone Names | 100603239 |
Gene ID | 10716 |
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Other Names | T-box brain protein 1, T-brain-1, TBR-1, TES-56, TBR1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TBR1 |
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Function | Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed:25232744, PubMed:30250039). As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity). |
Cellular Location | Nucleus |
Tissue Location | Brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of a conserved family of genes thatshare a common DNA-binding domain, the T-box. T-box genes encodetranscription factors involved in the regulation of developmentalprocesses. A similar protein has been disrupted in mice and shownto be critical for early cortical development, and causes loss ofprojection neurons in the olfactory bulbs and olfactory cortex. TheC-terminal region this similar protein was found to be necessaryand sufficient for association with the guanylate kinase domain ofcalcium/calmodulin-dependent serine protein kinase. [provided byRefSeq].
References
Hillier, L.W., et al. Nature 434(7034):724-731(2005)Stefanovska, A.M., et al. Cancer Res. 61(22):8351-8352(2001)Hsueh, Y.P., et al. Nature 404(6775):298-302(2000)Bulfone, A., et al. Neuron 15(1):63-78(1995)
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