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SLC22A18 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96BI1
Clone Names 100712301
Peptide ID 100712301
Additional Information
Gene ID 5002
Other Names Solute carrier family 22 member 18, Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein, Efflux transporter-like protein, Imprinted multi-membrane-spanning polyspecific transporter-related protein 1, Organic cation transporter-like protein 2, ORCTL-2, Solute carrier family 22 member 1-like, Tumor-suppressing STF cDNA 5 protein, Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein, p45-Beckwith-Wiedemann region 1 A, p45-BWR1A, SLC22A18
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC22A18
Function May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.
Cellular Location Apical cell membrane; Multi- pass membrane protein. Note=Localized at the apical membrane surface of renal proximal tubules
Tissue Location Expressed at high levels in adult and fetal kidney and liver, and adult colon. Expressed in fetal renal proximal tubules (at protein level). Expressed at lower levels in heart, brain and lung.
Research Areas
Citations (0)

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This gene is one of several tumor-suppressingsubtransferable fragments located in the imprinted gene domain of11p15.5, an important tumor-suppressor gene region. Alterations inthis region have been associated with the Beckwith-Wiedemannsyndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma,and lung, ovarian, and breast cancer. This gene is imprinted, withpreferential expression from the maternal allele. Mutations in thisgene have been found in Wilms' tumor and lung cancer. This proteinmay act as a transporter of organic cations, and have a role in thetransport of chloroquine and quinidine-related compounds in kidney.Two alternatively spliced transcript variants encoding the sameprotein have been described.


O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)Edenberg, H.J., et al. Alcohol. Clin. Exp. Res. 34(5):840-852(2010)Johnson, A.D., et al. Hum. Mol. Genet. 18(14):2700-2710(2009)Ali, A.M., et al. Gene 429 (1-2), 37-43 (2009) :Onyango, P., et al. Genome Res. 10(11):1697-1710(2000)

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$ 80.00
Cat# BP17804a
Availability: In Stock
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