|Other Names||Solute carrier family 22 member 18, Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein, Efflux transporter-like protein, Imprinted multi-membrane-spanning polyspecific transporter-related protein 1, Organic cation transporter-like protein 2, ORCTL-2, Solute carrier family 22 member 1-like, Tumor-suppressing STF cDNA 5 protein, Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein, p45-Beckwith-Wiedemann region 1 A, p45-BWR1A, SLC22A18|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.|
|Cellular Location||Apical cell membrane; Multi- pass membrane protein. Note=Localized at the apical membrane surface of renal proximal tubules|
|Tissue Location||Expressed at high levels in adult and fetal kidney and liver, and adult colon. Expressed in fetal renal proximal tubules (at protein level). Expressed at lower levels in heart, brain and lung.|
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This gene is one of several tumor-suppressingsubtransferable fragments located in the imprinted gene domain of11p15.5, an important tumor-suppressor gene region. Alterations inthis region have been associated with the Beckwith-Wiedemannsyndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma,and lung, ovarian, and breast cancer. This gene is imprinted, withpreferential expression from the maternal allele. Mutations in thisgene have been found in Wilms' tumor and lung cancer. This proteinmay act as a transporter of organic cations, and have a role in thetransport of chloroquine and quinidine-related compounds in kidney.Two alternatively spliced transcript variants encoding the sameprotein have been described.
O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)Edenberg, H.J., et al. Alcohol. Clin. Exp. Res. 34(5):840-852(2010)Johnson, A.D., et al. Hum. Mol. Genet. 18(14):2700-2710(2009)Ali, A.M., et al. Gene 429 (1-2), 37-43 (2009) :Onyango, P., et al. Genome Res. 10(11):1697-1710(2000)
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