|Other Names||Potassium channel subfamily K member 16, 2P domain potassium channel Talk-1, TWIK-related alkaline pH-activated K(+) channel 1, TALK-1, KCNK16, TALK1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Highly expressed in pancreas. Not detectable in the other tissues tested.|
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The protein encoded by this gene belongs to the family ofpotassium channel proteins containing two pore-forming P domains.This channel is an open rectifier which primarily passes outwardcurrent under physiological K+ concentrations. This gene isexpressed predominantly in the pancreas and is activated atalkaline pH. Several alternatively spliced transcript variantsencoding different isoforms have been identified for this gene.
Gierten, J., et al. Br. J. Pharmacol. 154(8):1680-1690(2008)Goldstein, S.A., et al. Pharmacol. Rev. 57(4):527-540(2005)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Han, J., et al. Am. J. Physiol., Cell Physiol. 285 (3), C529-C538 (2003) :Girard, C., et al. Biochem. Biophys. Res. Commun. 282(1):249-256(2001)
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