Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
DR1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q01658 |
|---|---|
| Clone Names | 100517033 |
| Gene ID | 1810 |
|---|---|
| Other Names | Protein Dr1, Down-regulator of transcription 1, Negative cofactor 2-beta, NC2-beta, TATA-binding protein-associated phosphoprotein, DR1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DR1 |
|---|---|
| Function | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. |
| Cellular Location | Nucleus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a TBP- (TATA box-binding protein)associated phosphoprotein that represses both basal and activatedlevels of transcription. The encoded protein is phosphorylated invivo and this phosphorylation affects its interaction with TBP.This protein contains a histone fold motif at the amino terminus, aTBP-binding domain, and a glutamine- and alanine-rich region. Thebinding of DR1 repressor complexes to TBP-promoter complexes mayestablish a mechanism in which an altered DNA conformation,together with the formation of higher order complexes, inhibits theassembly of the preinitiation complex and controls the rate of RNApolymerase II transcription.
References
Corneveaux, J.J., et al. Hum. Mol. Genet. 19(16):3295-3301(2010)Kantidakis, T., et al. Nucleic Acids Res. 38(4):1228-1239(2010)Albert, T.K., et al. Genome Biol. 11 (3), R33 (2010) :Kahle, J., et al. J. Biol. Chem. 284(14):9382-9393(2009)Wang, Y.L., et al. J. Biol. Chem. 283(49):33808-33815(2008)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
