|Other Names||Protein Dr1, Down-regulator of transcription 1, Negative cofactor 2-beta, NC2-beta, TATA-binding protein-associated phosphoprotein, DR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.|
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This gene encodes a TBP- (TATA box-binding protein)associated phosphoprotein that represses both basal and activatedlevels of transcription. The encoded protein is phosphorylated invivo and this phosphorylation affects its interaction with TBP.This protein contains a histone fold motif at the amino terminus, aTBP-binding domain, and a glutamine- and alanine-rich region. Thebinding of DR1 repressor complexes to TBP-promoter complexes mayestablish a mechanism in which an altered DNA conformation,together with the formation of higher order complexes, inhibits theassembly of the preinitiation complex and controls the rate of RNApolymerase II transcription.
Corneveaux, J.J., et al. Hum. Mol. Genet. 19(16):3295-3301(2010)Kantidakis, T., et al. Nucleic Acids Res. 38(4):1228-1239(2010)Albert, T.K., et al. Genome Biol. 11 (3), R33 (2010) :Kahle, J., et al. J. Biol. Chem. 284(14):9382-9393(2009)Wang, Y.L., et al. J. Biol. Chem. 283(49):33808-33815(2008)
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