|Other Names||Sodium-dependent phosphate transport protein 4, Na(+)/PI cotransporter 4, Sodium/phosphate cotransporter 4, Solute carrier family 17 member 3, SLC17A3, NPT4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.|
|Cellular Location||Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
SLC17A3 may be involved in actively transporting phosphate into cells via Na(+) cotransport (By similarity).
Jutabha, P., et al. J. Biol. Chem. 285(45):35123-35132(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Brandstatter, A., et al. Atherosclerosis 210(2):474-478(2010)Polasek, O., et al. Croat. Med. J. 51(1):32-39(2010)
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