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SLC17A3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O00476 |
|---|---|
| Clone Names | 110729210 |
| Gene ID | 10786 |
|---|---|
| Other Names | Sodium-dependent phosphate transport protein 4, Na(+)/PI cotransporter 4, Sodium/phosphate cotransporter 4, Solute carrier family 17 member 3, SLC17A3, NPT4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC17A3 |
|---|---|
| Synonyms | NPT4 |
| Function | [Isoform 2]: Transports organic anions in a voltage-driven, multispecific, manner, on the apical side of renal proximal tubule (PubMed:20810651). In particular, participates in the secretion of urate from the cell into the lumen (PubMed:20810651). Urate is the end product of purine metabolism (PubMed:20810651). May have roles in the metabolism and secretion of estrone sulfate, estradiol-17-beta- glucuronide, ochratoxin A, as wells as drugs such as bumetanide (PubMed:20810651). |
| Cellular Location | [Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in the liver and kidney (PubMed:9149941, PubMed:20810651). It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level) (PubMed:20810651) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC17A3 may be involved in actively transporting phosphate into cells via Na(+) cotransport (By similarity).
References
Jutabha, P., et al. J. Biol. Chem. 285(45):35123-35132(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Brandstatter, A., et al. Atherosclerosis 210(2):474-478(2010)Polasek, O., et al. Croat. Med. J. 51(1):32-39(2010)
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