|Other Names||HLA class I histocompatibility antigen, Cw-7 alpha chain, MHC class I antigen Cw*7, HLA-C, HLAC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the presentation of foreign antigens to the immune system.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
HLA-C belongs to the HLA class I heavy chain paralogues.This class I molecule is a heterodimer consisting of a heavy chainand a light chain (beta-2 microglobulin). The heavy chain isanchored in the membrane. Class I molecules play a central role inthe immune system by presenting peptides derived from endoplasmicreticulum lumen. They are expressed in nearly all cells. The heavychain is approximately 45 kDa and its gene contains 8 exons. Exonone encodes the leader peptide, exons 2 and 3 encode the alpha1 andalpha2 domain, which both bind the peptide, exon 4 encodes thealpha3 domain, exon 5 encodes the transmembrane region, and exons 6and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 andexon 3 are responsible for the peptide binding specificity of eachclass one molecule. Typing for these polymorphisms is routinelydone for bone marrow and kidney transplantation. Over one hundredHLA-C alleles have been described
Martin, M.P., et al. Immunogenetics 62 (11-12), 761-765 (2010) :Strange, A., et al. Nat. Genet. 42(11):985-990(2010)Noble, J.A., et al. Diabetes 59(11):2972-2979(2010)Honeyborne, I., et al. J. Virol. 84(21):11279-11288(2010)Healy, B.C., et al. Neurology 75(7):634-640(2010)
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