|Other Names||Anaphase-promoting complex subunit 4, APC4, Cyclosome subunit 4, ANAPC4, APC4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|
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Provided below are standard protocols that you may find useful for product applications.
A large protein complex, termed the anaphase-promotingcomplex (APC), or the cyclosome, promotes metaphase-anaphasetransition by ubiquitinating its specific substrates such asmitotic cyclins and anaphase inhibitor, which are subsequentlydegraded by the 26S proteasome. Biochemical studies have shown thatthe vertebrate APC contains eight subunits. The composition of theAPC is highly conserved in organisms from yeast to humans. Theexact function of this gene product is not known. [provided byRefSeq].
Wasch, R., et al. Oncogene 29(1):1-10(2010)Jin, L., et al. Cell 133(4):653-665(2008)Nature 447(7145):661-678(2007)Dube, P., et al. Mol. Cell 20(6):867-879(2005)Listovsky, T., et al. EMBO J. 23(7):1619-1626(2004)
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