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ADCY9 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O60503 |
|---|---|
| Clone Names | 90819061 |
| Gene ID | 115 |
|---|---|
| Other Names | Adenylate cyclase type 9, ATP pyrophosphate-lyase 9, Adenylate cyclase type IX, Adenylyl cyclase 9, ADCY9, KIAA0520 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ADCY9 |
|---|---|
| Synonyms | KIAA0520 |
| Function | Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta (PubMed:9628827, PubMed:10987815) Expressed in multiple cells of the lung, with expression highest in airway smooth muscle (PubMed:12972952). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Adenylate cyclase is a membrane bound enzyme thatcatalyses the formation of cyclic AMP from ATP. It is regulated bya family of G protein-coupled receptors, protein kinases, andcalcium. The type 9 adenylyl cyclase is a widely distributedadenylyl cyclase, and it is stimulated by beta-adrenergic receptoractivation but is insensitive to forskolin, calcium, andsomatostatin.
References
Wojcik, C., et al. Am. J. Med. Genet. A 152A (2), 479-483 (2010) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Tantisira, K.G., et al. Hum. Mol. Genet. 14(12):1671-1677(2005)Cumbay, M.G., et al. J. Pharmacol. Exp. Ther. 310(1):108-115(2004)Small, K.M., et al. Pharmacogenetics 13(9):535-541(2003)
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