|Other Names||Tyrosine-protein kinase RYK, Kinase VIK, Met-related kinase, NYK-R, Ryk, Mrk|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.|
|Cellular Location||Membrane; Single-pass type I membrane protein Nucleus. Cytoplasm. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus|
|Tissue Location||Is detected in all the tissues. Highest levels are seen in the ovary, lung and placenta|
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Provided below are standard protocols that you may find useful for product applications.
Ryk is potential growth factor receptor protein tyrosine kinase.
Buchert, M., et al. PLoS Genet. 6 (1), E1000816 (2010) :Lyu, J., et al. Dev. Cell 15(5):773-780(2008)Tamplin, O.J., et al. BMC Genomics 9, 511 (2008) :Keeble, T.R., et al. J. Neurosci. 26(21):5840-5848(2006)Schmitt, A.M., et al. Nature 439(7072):31-37(2006)
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