Mouse Ryk Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q01887 |
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Clone Names | 110328070 |
Gene ID | 20187 |
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Other Names | Tyrosine-protein kinase RYK, Kinase VIK, Met-related kinase, NYK-R, Ryk, Mrk |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Ryk |
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Synonyms | Mrk |
Function | May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. |
Cellular Location | Membrane; Single- pass type I membrane protein. Nucleus. Cytoplasm Note=In cells that have undergone neuronal differentiation, the C- terminal cleaved part is translocated from the cytoplasm to the nucleus |
Tissue Location | Is detected in all the tissues. Highest levels are seen in the ovary, lung and placenta |
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Provided below are standard protocols that you may find useful for product applications.
Background
Ryk is potential growth factor receptor protein tyrosine kinase.
References
Buchert, M., et al. PLoS Genet. 6 (1), E1000816 (2010) :Lyu, J., et al. Dev. Cell 15(5):773-780(2008)Tamplin, O.J., et al. BMC Genomics 9, 511 (2008) :Keeble, T.R., et al. J. Neurosci. 26(21):5840-5848(2006)Schmitt, A.M., et al. Nature 439(7072):31-37(2006)
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