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Mouse Bmpr2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O35607 |
|---|---|
| Clone Names | 110316055 |
| Gene ID | 12168 |
|---|---|
| Other Names | Bone morphogenetic protein receptor type-2, BMP type-2 receptor, BMPR-2, BRK-3, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, Bmpr2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Bmpr2 |
|---|---|
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (By similarity). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6 (PubMed:23527555). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q13873}; Single-pass type I membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
References
Talati, M., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 299 (3), L363-L373 (2010) :Libusova, L., et al. Development 137(14):2297-2305(2010)Podkowa, M., et al. Mol. Cell. Biol. 30(9):2241-2250(2010)Yang, C., et al. Ann. N. Y. Acad. Sci. 1192, 286-291 (2010) :Beppu, H., et al. Dev. Biol. 331(2):167-175(2009)
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