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Mouse Bmpr2 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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  • CITATIONS
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Product Information
Primary Accession O35607
Clone Names 110316055
Peptide ID 110316055
Additional Information
Gene ID 12168
Other Names Bone morphogenetic protein receptor type-2, BMP type-2 receptor, BMPR-2, BRK-3, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, Bmpr2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Bmpr2
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6 (PubMed:23527555).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q13873}; Single-pass type I membrane protein
Research Areas
Citations (0)

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Background

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.

References

Talati, M., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 299 (3), L363-L373 (2010) :Libusova, L., et al. Development 137(14):2297-2305(2010)Podkowa, M., et al. Mol. Cell. Biol. 30(9):2241-2250(2010)Yang, C., et al. Ann. N. Y. Acad. Sci. 1192, 286-291 (2010) :Beppu, H., et al. Dev. Biol. 331(2):167-175(2009)

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$ 80.00
Cat# BP17916b
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