|Other Names||Nectin-4, Ig superfamily receptor LNIR, Poliovirus receptor-related protein 4, Processed poliovirus receptor-related protein 4, PVRL4, LNIR, PRR4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction. Note=Colocalizes with MLLT4 at cadherin-based adherens junctions|
|Tissue Location||Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.|
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Provided below are standard protocols that you may find useful for product applications.
Poliovirus receptor-like proteins (PVRLs), such as PVRL4,are adhesion receptors of the immunoglobulin superfamily andfunction in cell-cell adhesion (Reymond et al., 2001 [PubMed11544254]).
Derycke, M.S., et al. Am. J. Clin. Pathol. 134(5):835-845(2010)Brancati, F., et al. Am. J. Hum. Genet. 87(2):265-273(2010)Takano, A., et al. Cancer Res. 69(16):6694-6703(2009)Fabre-Lafay, S., et al. BMC Cancer 7, 73 (2007) :Fabre-Lafay, S., et al. J. Biol. Chem. 280(20):19543-19550(2005)
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