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PVRL4 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96NY8 |
|---|---|
| Clone Names | 110726175 |
| Gene ID | 81607 |
|---|---|
| Other Names | Nectin-4, Ig superfamily receptor LNIR, Poliovirus receptor-related protein 4, Processed poliovirus receptor-related protein 4, PVRL4, LNIR, PRR4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NECTIN4 (HGNC:19688) |
|---|---|
| Synonyms | LNIR, PRR4, PVRL4 |
| Function | Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction. Note=Colocalizes with AFDN at cadherin- based adherens junctions (PubMed:11544254) |
| Tissue Location | Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma |
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Provided below are standard protocols that you may find useful for product applications.
Background
Poliovirus receptor-like proteins (PVRLs), such as PVRL4,are adhesion receptors of the immunoglobulin superfamily andfunction in cell-cell adhesion (Reymond et al., 2001 [PubMed11544254]).
References
Derycke, M.S., et al. Am. J. Clin. Pathol. 134(5):835-845(2010)Brancati, F., et al. Am. J. Hum. Genet. 87(2):265-273(2010)Takano, A., et al. Cancer Res. 69(16):6694-6703(2009)Fabre-Lafay, S., et al. BMC Cancer 7, 73 (2007) :Fabre-Lafay, S., et al. J. Biol. Chem. 280(20):19543-19550(2005)
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