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GBP4 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96PP9 |
|---|---|
| Clone Names | 110811082 |
| Gene ID | 115361 |
|---|---|
| Other Names | Guanylate-binding protein 4, GTP-binding protein 4, GBP-4, Guanine nucleotide-binding protein 4, GBP4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GBP4 {ECO:0000303|Ref.1, ECO:0000312|HGNC:HGNC:20480} |
|---|---|
| Function | Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Negatively regulates the antiviral response by inhibiting activation of IRF7 transcription factor (By similarity). |
| Cellular Location | Golgi apparatus membrane. Cytoplasm Nucleus. Cytoplasm, perinuclear region. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP5, at the Golgi apparatus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Guanylate-binding proteins, such as GBP4, are induced byinterferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005[PubMed 16108726]).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Olszewski, M.A., et al. J. Interferon Cytokine Res. 26(5):328-352(2006)Vestal, D.J. J. Interferon Cytokine Res. 25(8):435-443(2005)Han, B.H., et al. Biochim. Biophys. Acta 1384(2):373-386(1998)
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