|Other Names||Guanylate-binding protein 4, GTP-binding protein 4, GBP-4, Guanine nucleotide-binding protein 4, GBP4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Golgi apparatus membrane. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP-5, at the Golgi aparatus|
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Provided below are standard protocols that you may find useful for product applications.
Guanylate-binding proteins, such as GBP4, are induced byinterferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005[PubMed 16108726]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Olszewski, M.A., et al. J. Interferon Cytokine Res. 26(5):328-352(2006)Vestal, D.J. J. Interferon Cytokine Res. 25(8):435-443(2005)Han, B.H., et al. Biochim. Biophys. Acta 1384(2):373-386(1998)
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