|Other Names||Programmed cell death protein 10, Cerebral cavernous malformations 3 protein, TF-1 cell apoptosis-related protein 15, PDCD10, CCM3, TFAR15|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).|
|Cellular Location||Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Partially co- localizes with endogenous PXN at the leading edges of migrating cells|
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This gene encodes an evolutionarily conserved proteinassociated with cell apoptosis. The protein interacts with theserine/threonine protein kinase MST4 to modulate the extracellularsignal-regulated kinase (ERK) pathway. It also interacts with andis phosphoryated by serine/threonine kinase 25, and is thought tofunction in a signaling pathway essential for vascular developent.Mutations in this gene are one cause of cerebral cavernousmalformations, which are vascular malformations that cause seizuresand cerebral hemorrhages. Multiple alternatively spliced variants,encoding the same protein, have been identified. [provided byRefSeq].
Lauenborg, B., et al. APMIS 118(10):719-728(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Ding, J., et al. Biochem. Biophys. Res. Commun. 399(4):587-592(2010)Zheng, X., et al. J. Clin. Invest. 120(8):2795-2804(2010)Dibble, C.F., et al. PLoS ONE 5 (7), E11740 (2010) :
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