DMGDH Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UI17 |
---|---|
Clone Names | 90921125 |
Gene ID | 29958 |
---|---|
Other Names | Dimethylglycine dehydrogenase, mitochondrial, ME2GLYDH, DMGDH |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DMGDH |
---|---|
Function | Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro. |
Cellular Location | Mitochondrion. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme involved in the catabolism ofcholine, catalyzing the oxidative demethylation of dimethylglycineto form sarcosine. The enzyme is found as a monomer in themitochondrial matrix, and uses flavin adenine dinucleotide andfolate as cofactors. Mutation in this gene causes dimethylglycinedehydrogenase deficiency, characterized by a fishlike body odor,chronic muscle fatigue, and elevated levels of the muscle form ofcreatine kinase in serum.
References
Mostowska, A., et al. Eur. J. Oral Sci. 118(4):325-332(2010)Bailey, S.D., et al. Diabetes Care (2010) In press :Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Boyles, A.L., et al. Genet. Epidemiol. 33(3):247-255(2009)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.