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SLC12A4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UP95 |
|---|---|
| Clone Names | 100712192 |
| Gene ID | 6560 |
|---|---|
| Other Names | Solute carrier family 12 member 4, Electroneutral potassium-chloride cotransporter 1, Erythroid K-Cl cotransporter 1, hKCC1, SLC12A4, KCC1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC12A4 (HGNC:10913) |
|---|---|
| Function | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Ubiquitous (PubMed:8663127, PubMed:9516379). Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes (PubMed:9516379). This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS (PubMed:9516379). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC12A4 mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Zhang, S., et al. Eur. J. Gynaecol. Oncol. 30(1):29-34(2009)Zhou, G.P., et al. Blood 103(11):4302-4309(2004)
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