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SLC12A4 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UP95
Clone Names 100712192
Peptide ID 100712192
Additional Information
Gene ID 6560
Other Names Solute carrier family 12 member 4, Electroneutral potassium-chloride cotransporter 1, Erythroid K-Cl cotransporter 1, hKCC1, SLC12A4, KCC1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC12A4
Synonyms KCC1
Function Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes
Research Areas
Citations (0)

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Background

SLC12A4 mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.

References

Bailey, S.D., et al. Diabetes Care (2010) In press :Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Zhang, S., et al. Eur. J. Gynaecol. Oncol. 30(1):29-34(2009)Zhou, G.P., et al. Blood 103(11):4302-4309(2004)

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$ 80.00
Cat# BP18058b
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