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NUBPL Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8TB37 |
|---|---|
| Clone Names | 110726145 |
| Gene ID | 80224 |
|---|---|
| Other Names | Iron-sulfur protein NUBPL, IND1 homolog, Nucleotide-binding protein-like, huInd1, NUBPL, C14orf127 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NUBPL |
|---|---|
| Synonyms | C14orf127 |
| Function | Iron-sulfur cluster transfer protein involved in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:19752196). May deliver one or more Fe-S clusters to complex I subunits (PubMed:19752196). |
| Cellular Location | Mitochondrion. |
| Tissue Location | Highest expression in liver and kidney. expressed at significant levels in small intestine and brain (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Respiratory complex I (NADH:ubiquinone oxidoreductase EC1.6.5.3) is a large mitochondrial inner membrane enzyme consistingof 45 subunits and 8 iron-sulfur (Fe/S) clusters. NUBPL, or IND1,is an Fe/ S protein that plays a critical role in the assembly ofrespiratory complex I, likely by transferring Fe/S into theFe/S-containing complex I subunits (Sheftel et al., 2009 [PubMed19752196]).
References
Calvo, S.E., et al. Nat. Genet. 42(10):851-858(2010)Sheftel, A.D., et al. Mol. Cell. Biol. 29(22):6059-6073(2009)Volpi, S., et al. Mol. Psychiatry 14(11):1024-1031(2009)Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)
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