|Other Names||Membrane-spanning 4-domains subfamily A member 3, CD20 antigen-like protein, Hematopoietic-specific transmembrane protein 4, HTm4, MS4A3, CD20L, HTM4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin- dependent kinase 2 (CDK2) through its direct binding to cyclin- dependent kinase inhibitor 3 (CDKN3/KAP).|
|Cellular Location||Endomembrane system; Multi- pass membrane protein. Cytoplasm, perinuclear region. Note=Located in the perinuclear area|
|Tissue Location||Expressed specifically in hematopoietic cells and tissues|
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This gene encodes a member of the membrane-spanning 4Agene family. Members of this protein family are characterized bycommon structural features and similar intron/exon spliceboundaries and display unique expression patterns amonghematopoietic cells and nonlymphoid tissues. This family memberlikely plays a role in signal transduction and may function as asubunit associated with receptor complexes. The gene encoding thisprotein is localized to 11q12, among a cluster of related familymembers. Alternative splicing may result in multiple transcriptvariants; however, not all variants have been fully described.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Lamesch, P., et al. Genomics 89(3):307-315(2007)Chinami, M., et al. J. Biol. Chem. 280(17):17235-17242(2005)Donato, J.L., et al. J. Clin. Invest. 109(1):51-58(2002)
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