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PPIL5 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96L50 |
|---|---|
| Clone Names | 110811174 |
| Gene ID | 122769 |
|---|---|
| Other Names | Leucine-rich repeat protein 1, 4-1BB-mediated-signaling molecule, 4-1BBlrr, LRR-repeat protein 1, LRR-1, Peptidylprolyl isomerase-like 5, LRR1, PPIL5 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LRR1 (HGNC:19742) |
|---|---|
| Synonyms | PPIL5 |
| Function | Substrate recognition subunit of an ECS (Elongin BC-CUL2/5- SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S- phase (By similarity). May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1 (PubMed:11804328). |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitous. Maximal expression was seen in the heart and skeletal muscle and minimal expression seen in the kidney |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene contains a leucine-richrepeat (LRR). It specifically interacts with TNFRSF9/4-1BB, amember of the tumor necrosis factor receptor (TNFR) superfamily.Overexpression of this gene suppresses the activation of NF-kappa Binduced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2),which suggests that this protein is a negative regulator ofTNFRSF9-mediated signaling cascades. At least three alternativelyspliced transcript variants encoding distinct isoforms have beenobserved.
References
Jang, L.K., et al. Mol. Cells 12(3):304-312(2001)
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