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PPIL5 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96L50
Clone Names 110811174
Peptide ID 110811174
Additional Information
Gene ID 122769
Other Names Leucine-rich repeat protein 1, 4-1BB-mediated-signaling molecule, 4-1BBlrr, LRR-repeat protein 1, LRR-1, Peptidylprolyl isomerase-like 5, LRR1, PPIL5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRR1
Synonyms PPIL5
Function May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Tissue Location Ubiquitous. Maximal expression was seen in the heart and skeletal muscle and minimal expression seen in the kidney
Research Areas
Citations (0)

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Background

The protein encoded by this gene contains a leucine-richrepeat (LRR). It specifically interacts with TNFRSF9/4-1BB, amember of the tumor necrosis factor receptor (TNFR) superfamily.Overexpression of this gene suppresses the activation of NF-kappa Binduced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2),which suggests that this protein is a negative regulator ofTNFRSF9-mediated signaling cascades. At least three alternativelyspliced transcript variants encoding distinct isoforms have beenobserved.

References

Jang, L.K., et al. Mol. Cells 12(3):304-312(2001)

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$ 80.00
Cat# BP18105c
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