|Other Names||Leucine-rich repeat protein 1, 4-1BB-mediated-signaling molecule, 4-1BBlrr, LRR-repeat protein 1, LRR-1, Peptidylprolyl isomerase-like 5, LRR1, PPIL5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.|
|Tissue Location||Ubiquitous. Maximal expression was seen in the heart and skeletal muscle and minimal expression seen in the kidney|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene contains a leucine-richrepeat (LRR). It specifically interacts with TNFRSF9/4-1BB, amember of the tumor necrosis factor receptor (TNFR) superfamily.Overexpression of this gene suppresses the activation of NF-kappa Binduced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2),which suggests that this protein is a negative regulator ofTNFRSF9-mediated signaling cascades. At least three alternativelyspliced transcript variants encoding distinct isoforms have beenobserved.
Jang, L.K., et al. Mol. Cells 12(3):304-312(2001)
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