|Other Names||Pyroglutamylated RFamide peptide receptor, AQ27, G-protein coupled receptor 103, Orexigenic neuropeptide QRFP receptor, SP9155, QRFPR, GPR103|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and medulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart, kidney, testis and thyroid|
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Provided below are standard protocols that you may find useful for product applications.
G protein-coupled receptors (GPCRs, or GPRs) contain 7transmembrane domains and transduce extracellular signals throughheterotrimeric G proteins.
Mulumba, M., et al. Mol. Endocrinol. 24(8):1615-1625(2010)Dowal, L., et al. J. Biol. Chem. 281(33):23999-24014(2006)Takayasu, S., et al. Proc. Natl. Acad. Sci. U.S.A. 103(19):7438-7443(2006)Fukusumi, S., et al. J. Biol. Chem. 278(47):46387-46395(2003)Jiang, Y., et al. J. Biol. Chem. 278(30):27652-27657(2003)
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