TRIM24 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O15164 |
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Clone Names | 50908263 |
Gene ID | 8805 |
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Other Names | Transcription intermediary factor 1-alpha, TIF1-alpha, 632-, E3 ubiquitin-protein ligase TRIM24, RING finger protein 82, Tripartite motif-containing protein 24, TRIM24, RNF82, TIF1, TIF1A |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TRIM24 |
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Synonyms | RNF82, TIF1, TIF1A |
Function | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up- regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Participates also in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL- 1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). |
Cellular Location | Nucleus. Cytoplasm. Mitochondrion. Note=Colocalizes with sites of active transcription. Predominantly nuclear. Translocated from nucleus to mitochondria to mediate antiviral immunity (PubMed:32324863). Localizes to sites of DNA damage (PubMed:25593309). |
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Background
The protein encoded by this gene mediates transcriptionalcontrol by interaction with the activation function 2 (AF2) regionof several nuclear receptors, including the estrogen, retinoicacid, and vitamin D3 receptors. The protein localizes to nuclearbodies and is thought to associate with chromatin andheterochromatin-associated factors. The protein is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains - a RING, a B-box type 1 and a B-box type 2 -and a coiled-coil region. Two alternatively spliced transcriptvariants encoding different isoforms have been described for thisgene.
References
Kikuchi, M., et al. Biochim. Biophys. Acta 1793(12):1828-1836(2009)Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Yondola, M.A., et al. J. Virol. 81(8):4264-4271(2007)
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