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ARSA Antibody (C-term) Blocking Peptide
Synthetic peptide
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- BACKGROUND
| Primary Accession | O43681 |
|---|---|
| Clone Names | 90429032 |
| Gene ID | 439 |
|---|---|
| Other Names | ATPase ASNA1 {ECO:0000255|HAMAP-Rule:MF_03112}, 36-- {ECO:0000255|HAMAP-Rule:MF_03112}, Arsenical pump-driving ATPase {ECO:0000255|HAMAP-Rule:MF_03112}, Arsenite-stimulated ATPase {ECO:0000255|HAMAP-Rule:MF_03112}, Transmembrane domain recognition complex 40 kDa ATPase subunit, hARSA-I, hASNA-I, ASNA1 {ECO:0000255|HAMAP-Rule:MF_03112}, ARSA, TRC40 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GET3 {ECO:0000255|HAMAP-Rule:MF_03112, ECO:0000312|HGNC:HGNC:752} |
|---|---|
| Function | ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling. |
| Cellular Location | Cytoplasm. Endoplasmic reticulum. Nucleus, nucleolus |
| Tissue Location | Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ASNA1 is the human homolog of the bacterial arsA gene. InE. coli, ArsA ATPase is the catalytic component of a multisubunitoxyanion pump that is responsible for resistance to arsenicals andantimonials.
References
Favaloro, V., et al. J. Cell. Sci. 123 (PT 9), 1522-1530 (2010) :Hemmingsson, O., et al. Oncol. Rep. 22(4):869-875(2009)Rabu, C., et al. J. Biol. Chem. 283(41):27504-27513(2008)Stefanovic, S., et al. Cell 128(6):1147-1159(2007)Kao, G., et al. Cell 128(3):577-587(2007)
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