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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   FIG4 Antibody (C-term) Blocking Peptide   

FIG4 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q92562
Clone Names 91102112
Peptide ID 91102112
Additional Information
Gene ID 9896
Other Names Polyphosphoinositide phosphatase, 313-, Phosphatidylinositol 3, 5-bisphosphate 5-phosphatase, SAC domain-containing protein 3, FIG4, KIAA0274, SAC3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FIG4
Synonyms KIAA0274, SAC3
Function The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
Cellular Location Endosome membrane. Note=Localization requires VAC14 and PIKFYVE
Research Areas
Citations (0)

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The protein encoded by this gene belongs to the SACdomain-containing protein gene family. The SAC domain,approximately 400 amino acids in length and consisting of sevenconserved motifs, has been shown to possess phosphoinositidephosphatase activity. The yeast homolog, Sac1p, is involved in theregulation of various phosphoinositides, and affects diversecellular functions such as actin cytoskeleton organization, Golgifunction, and maintenance of vacuole morphology. Membrane-boundphosphoinositides function as signaling molecules and play a keyrole in vesicle trafficking in eukaryotic cells. Mutations in thisgene have been associated with Charcot-Marie-Tooth disease, type4J.


Ikonomov, O.C., et al. J. Biol. Chem. 285(35):26760-26764(2010)Tsai, C.P., et al. Neurobiol. Aging (2010) In press :Ikonomov, O.C., et al. J. Biol. Chem. 284(51):35794-35806(2009)Soranzo, N., et al. Nat. Genet. 41(11):1182-1190(2009)Trynka, G., et al. Gut 58(8):1078-1083(2009)

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$ 80.00
Cat# BP18145b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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