|Other Names||Extracellular glycoprotein lacritin, LACRT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Modulates secretion by lacrimal acinar cells.|
|Tissue Location||Expressed in secretory granules of many acinar cells in lacrimal gland and in scattered acinar cells of salivary glands EMBL; AY005150; AAG32949.1; -; Genomic_DNA EMBL; AF238867; AAG44392.1; -; mRNA EMBL; BC062217; AAH62217.1; -; mRNA EMBL; BC069317; AAH69317.1; -; mRNA CCDS; CCDS8883.1; - RefSeq; NP_150593.1; NM_033277.1 UniGene; Hs.307096; - ProteinModelPortal; Q9GZZ8; - SMR; Q9GZZ8; - BioGrid; 124659; 38 IntAct; Q9GZZ8; 3 STRING; 9606.ENSP00000257867; - iPTMnet; Q9GZZ8; - PhosphoSitePlus; Q9GZZ8; - BioMuta; LACRT; - DMDM; 33301325; - MaxQB; Q9GZZ8; - PaxDb; Q9GZZ8; - PeptideAtlas; Q9GZZ8; - PRIDE; Q9GZZ8; - DNASU; 90070; - Ensembl; ENST00000257867; ENSP00000257867; ENSG00000135413 GeneID; 90070; - KEGG; hsa:90070; - UCSC; uc001sgi.2; human CTD; 90070; - DisGeNET; 90070; - GeneCards; LACRT; - HGNC; HGNC:16430; LACRT MIM; 607360; gene neXtProt; NX_Q9GZZ8; - OpenTargets; ENSG00000135413; - PharmGKB; PA30261; - eggNOG; ENOG410KH2Q; Eukaryota eggNOG; ENOG4110RQ2; LUCA GeneTree; ENSGT00390000008599; - HOGENOM; HOG000113273; - HOVERGEN; HBG052295; - InParanoid; Q9GZZ8; - OMA; QELNPLK; - OrthoDB; EOG091G13ZK; - PhylomeDB; Q9GZZ8; - TreeFam; TF340896; - BioCyc; ZFISH:ENSG00000135413-MONOMER; - ChiTaRS; LACRT; human GeneWiki; Lacritin; - GenomeRNAi; 90070; - PRO; PR:Q9GZZ8; - Proteomes; UP000005640; Chromosome 12 Bgee; ENSG00000135413; - CleanEx; HS_LACRT; - ExpressionAtlas; Q9GZZ8; baseline and differential Genevisible; Q9GZZ8; HS GO; GO:0005576; C:extracellular region; IDA:UniProtKB GO; GO:0005615; C:extracellular space; IDA:UniProtKB GO; GO:0030141; C:secretory granule; IDA:UniProtKB GO; GO:0005518; F:collagen binding; IDA:UniProtKB GO; GO:0001968; F:fibronectin binding; IDA:UniProtKB GO; GO:0001948; F:glycoprotein binding; IDA:UniProtKB GO; GO:0008083; F:growth factor activity; IDA:UniProtKB GO; GO:0043237; F:laminin-1 binding; IDA:UniProtKB GO; GO:0047485; F:protein N-terminus binding; IPI:UniProtKB GO; GO:0033173; P:calcineurin-NFAT signaling cascade; IDA:UniProtKB GO; GO:0019722; P:calcium-mediated signaling; IDA:UniProtKB GO; GO:0042742; P:defense response to bacterium; IDA:FlyBase GO; GO:0010669; P:epithelial structure maintenance; IDA:FlyBase GO; GO:0043066; P:negative regulation of apoptotic process; IDA:FlyBase GO; GO:0031665; P:negative regulation of lipopolysaccharide-mediated signaling pathway; IDA:FlyBase GO; GO:0050850; P:positive regulation of calcium-mediated signaling; IDA:FlyBase GO; GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IDA:UniProtKB GO; GO:0060054; P:positive regulation of epithelial cell proliferation involved in wound healing; IDA:FlyBase GO; GO:0016239; P:positive regulation of macroautophagy; IDA:FlyBase GO; GO:0051533; P:positive regulation of NFAT protein import into nucleus; IDA:UniProtKB GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:UniProtKB GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB GO; GO:0051047; P:positive regulation of secretion; IDA:UniProtKB GO; GO:0006473; P:protein acetylation; IMP:FlyBase GO; GO:0034067; P:protein localization to Golgi apparatus; IDA:UniProtKB GO; GO:0070075; P:tear secretion; NAS:UniProtKB InterPro; IPR033530; Lacritin PANTHER; PTHR40711:SF2; PTHR40711:SF2; 1 1: Evidence at protein level; Complete proteome; Direct protein sequencing; Glycoprotein; Reference proteome; Secreted; Signal SIGNAL 1 19 CHAIN 20 138 Extracellular glycoprotein lacritin /FTId=PRO_0000021574 CARBOHYD 119 119 N-linked (GlcNAc...) SEQUENCE 138 AA; 14246 MW; 09910581E650F6FF CRC64; MKFTTLLFLA AVAGALVYAE DASSDSTGAD PAQEAGTSKP NEEISGPAEP ASPPETTTTA QETSAAAVQG TAKVTSSRQE LNPLKSIVEK SILLTEQALA KAGKGMHGGV PGGKQFIENG SEFAQKLLKK FSLLKPWA|
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The protein encoded by this gene is highly expressed inthe lacrimal glands and localized primarily to secretory granulesand secretory fluid. It augments lacrimal acinar cell secretion,promotes ductal cell proliferation, and stimulates signalingthrough tyrosine phosphorylation and release of calcium. [providedby RefSeq].
Morimoto-Tochigi, A., et al. Invest. Ophthalmol. Vis. Sci. 51(9):4395-4406(2010)Nichols, J.J., et al. Cornea 28(10):1109-1117(2009)McKown, R.L., et al. Exp. Eye Res. 88(5):848-858(2009)Lei, Z., et al. J. Proteome Res. 8(4):1992-2003(2009)Green-Church, K.B., et al. Mol. Vis. 14, 291-297 (2008) :
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