|Other Names||Eukaryotic translation initiation factor 2 subunit 3, Eukaryotic translation initiation factor 2 subunit gamma X, eIF-2-gamma X, eIF-2gX, EIF2S3, EIF2G|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).|
|Tissue Location||Expressed in testis, brain, liver and muscle.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is the largest subunit ofa heterotrimeric GTP-binding protein involved in the recruitment ofmethionyl-tRNA(i) to the 40 S ribosomal subunit. [provided byRefSeq].
Burkhardt, J., et al. J. Rheumatol. 36(10):2149-2157(2009)Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Mikami, S., et al. Protein Expr. Purif. 46(2):348-357(2006)
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