|Other Names||Nck-associated protein 1-like, Hematopoietic protein 1, Membrane-associated protein HEM-1, NCKAP1L, HEM1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cell membrane; Single-pass membrane protein; Cytoplasmic side|
|Tissue Location||Expressed only in cells of hematopoietic origin|
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This gene encodes a member of the HEM family oftissue-specific transmembrane proteins which are highly conservedfrom invertebrates through mammals. This gene is only expressed inhematopoietic cells. The encoded protein is a part of the Scar/WAVEcomplex which plays an important role in regulating cell shape inboth metazoans and plants. Alternatively spliced transcriptvariants encoding different isoforms have been found.
Joshi, A.D., et al. Clin. Cancer Res. 13 (18 PT 1), 5295-5304 (2007) :Weiner, O.D., et al. PLoS Biol. 5 (9), E221 (2007) :Weiner, O.D., et al. PLoS Biol. 4 (2), E38 (2006) :Baumgartner, S., et al. J. Mol. Biol. 251(1):41-49(1995)Hromas, R., et al. Biochim. Biophys. Acta 1090(2):241-244(1991)
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