|Other Names||UDP-glucuronosyltransferase 2B7, UDPGT 2B7, 4-catechol estrogen-specific UDPGT, UDP-glucuronosyltransferase 2B9, UDPGT 2B9, UDPGTh-2, UGT2B7, UGTB2B9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.|
|Cellular Location||Microsome membrane; Single- pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The UGTs (EC 22.214.171.124) serve a major role in theconjugation and subsequent elimination of potentially toxicxenobiotics and endogenous compounds. UGT2B7 has unique specificityfor 3,4-catechol estrogens and estriol, suggesting that it may playan important role in regulating the level and activity of thesepotent estrogen metabolites. Its subcellular location is themicrosome.
Joy, M.S., et al. Eur. J. Clin. Pharmacol. 66(11):1119-1130(2010)Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)Woillard, J.B., et al. Br J Clin Pharmacol 69(6):675-683(2010)Hwang, M.S., et al. Drug Metab. Pharmacokinet. 25(4):398-402(2010)
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