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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   DRAP1 Antibody (N-term) Blocking Peptide   

DRAP1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14919
Clone Names 100318203
Peptide ID 100318203
Additional Information
Gene ID 10589
Other Names Dr1-associated corepressor, Dr1-associated protein 1, Negative cofactor 2-alpha, NC2-alpha, DRAP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DRAP1
Function The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
Cellular Location Nucleus.
Tissue Location Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney.
Research Areas
Citations (0)

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Transcriptional repression is a general mechanism forregulating transcriptional initiation in organisms ranging fromyeast to humans. Accurate initiation of transcription fromeukaryotic protein-encoding genes requires the assembly of a largemultiprotein complex consisting of RNA polymerase II and generaltranscription factors such as TFIIA, TFIIB, and TFIID. DR1 is arepressor that interacts with the TATA-binding protein (TBP) ofTFIID and prevents the formation of an active transcription complexby precluding the entry of TFIIA and/or TFIIB into thepreinitiation complex. The protein encoded by this gene is acorepressor of transcription that interacts with DR1 to enhanceDR1-mediated repression. The interaction between this corepressorand DR1 is required for corepressor function and appears tostabilize the TBP-DR1-DNA complex.


Kahle, J., et al. J. Biol. Chem. 284(14):9382-9393(2009)Schluesche, P., et al. Nat. Struct. Mol. Biol. 14(12):1196-1201(2007)Albert, T.K., et al. Proc. Natl. Acad. Sci. U.S.A. 104(24):10000-10005(2007)Lim, J., et al. Cell 125(4):801-814(2006)Assmann, E.M., et al. J. Biol. Chem. 281(15):9869-9881(2006)

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$ 80.00
Cat# BP18211a
Availability: In Stock
Bulk Size
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