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GABARAP Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O95166
Clone Names 70226110
Peptide ID 70226110
Additional Information
Gene ID 11337
Other Names Gamma-aminobutyric acid receptor-associated protein, GABA(A) receptor-associated protein, MM46, GABARAP, FLC3B
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1821a was selected from the N-term region of human Autophagy GABARAP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GABARAP
Synonyms FLC3B
Function Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
Cellular Location Endomembrane system. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P60517}. Golgi apparatus membrane. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P60517}. Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:P60517, ECO:0000250|UniProtKB:Q9DCD6}
Tissue Location Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
Research Areas
Citations (0)

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Background

Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. GABARAP is GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.

References

Nemos, C., et al., Brain Res. Mol. Brain Res. 119(2):216-219 (2003).Stangler, T., et al., J. Biol. Chem. 277(16):13363-13366 (2002).Knight, D., et al., J. Biol. Chem. 277(7):5556-5561 (2002).Tanida, I., et al., J. Biol. Chem. 277(16):13739-13744 (2002).Harris, R., et al., J. Biomol. NMR 21(2):185-186 (2001).

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$ 80.00
Cat# BP1821a
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