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FGF19 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95750 |
|---|---|
| Clone Names | 100623228 |
| Gene ID | 9965 |
|---|---|
| Other Names | Fibroblast growth factor 19, FGF-19, FGF19 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FGF19 |
|---|---|
| Function | Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in fetal brain, cartilage, retina, and adult gall bladder. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of thefibroblast growth factor (FGF) family. FGF family members possessbroad mitogenic and cell survival activities, and are involved in avariety of biological processes including embryonic developmentcell growth, morphogenesis, tissue repair, tumor growth andinvasion. This growth factor is a high affinity, heparin dependentligand for FGFR4. Expression of this gene was detected only infetal but not adult brain tissue. Synergistic interaction of thechick homolog and Wnt-8c has been shown to be required forinitiation of inner ear development.
References
Rao, A.S., et al. Gastroenterology 139(5):1549-1558(2010)Turnbull, C., et al. Nat. Genet. 42(6):504-507(2010)Schreuder, T.C., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 298 (3), G440-G445 (2010) :Reiche, M., et al. Horm. Metab. Res. 42(3):178-181(2010)Wu, X., et al. J. Biol. Chem. 285(8):5165-5170(2010)
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