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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   LRRC16A Antibody (C-term) Blocking Peptide   

LRRC16A Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q5VZK9
Clone Names 110726116
Peptide ID 110726116
Additional Information
Gene ID 55604
Other Names Leucine-rich repeat-containing protein 16A, CARMIL homolog, LRRC16A, CARMIL, CARMIL1a, LRRC16
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CARL1
Function Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667).
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6EDY6}. Cell membrane. Cell projection, lamellipodium. Note=Colocalized with heterodimeric capping protein (CP) and F-actin in lamellipodia but not with F-actin in stress fibers (PubMed:19846667). Colocalized with F-actin in lamellipodia but not with F-actin in stress fibers (PubMed:19846667). Found on macropinosomes (PubMed:19846667) {ECO:0000250|UniProtKB:Q6EDY6, ECO:0000269|PubMed:19846667}
Tissue Location Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney.
Research Areas
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Background

LRRC16A binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization (By similarity).

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Polasek, O., et al. Croat. Med. J. 51(1):32-39(2010)Gunjaca, G., et al. Croat. Med. J. 51(1):23-31(2010)van der Harst, P., et al. Hum. Mol. Genet. 19(2):387-395(2010)Liang, Y., et al. Mol. Biol. Cell 20(24):5290-5305(2009)

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$ 80.00
Cat# BP18234b
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