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ELL3 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9HB65
Clone Names 110811068
Peptide ID 110811068
Additional Information
Gene ID 80237
Other Names RNA polymerase II elongation factor ELL3, ELL3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ELL3
Function Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968).
Cellular Location Nucleus.
Tissue Location Testis specific.
Research Areas
Citations (0)

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ELL3 is a elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.


Lamesch, P., et al. Genomics 89(3):307-315(2007)Miller, T., et al. J. Biol. Chem. 275(41):32052-32056(2000)

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$ 80.00
Cat# BP18266b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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