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SLC22A13 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y226 |
|---|---|
| Clone Names | 110811212 |
| Gene ID | 9390 |
|---|---|
| Other Names | Solute carrier family 22 member 13, Organic cation transporter-like 3, ORCTL-3, SLC22A13, OCTL1, ORCTL3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC22A13 (HGNC:8494) |
|---|---|
| Function | Anion antiporter that mediates the transport of urate, orotate and nicotinate in exchange for organic or inorganic anions (PubMed:18411268, PubMed:35144162, PubMed:31780526, PubMed:35462902). Translocates urate and orotate across the apical membrane of proximal tubule epithelial cells and involved in urate renal reabsorption (PubMed:18411268, PubMed:35144162, PubMed:31780526). Possibly involved in orotate renal reabsorption and nicotinate intestinal reabsorption (PubMed:18411268, PubMed:35144162). Mediates urate uptake by an exchange with organic anions such as (S)-lactate, succinate, glutathione and nicotinate (PubMed:18411268). Urate and orotate transports are Cl(-)-dependent (PubMed:35144162, PubMed:35462902). Shows similar transport characteristics as the urate/orotate renal antiporter SLC22A12/URAT1 and may act as a compensator of SLC22A12/URAT1 in certain conditions (Probable). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein |
| Tissue Location | Ubiquitous (PubMed:10072596). Highly expressed in kidneys and to a weaker extent in brain, heart, and intestine (PubMed:18411268). In kidneys, expressed in proximal convoluted tubule (PubMed:18411268, PubMed:31780526, PubMed:35462902). In kidneys, also expressed in cortical collecting duct, whereas glomerulus and thick ascending limb exhibit no expression (PubMed:18411268) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the organic-cationtransporter family. It is located in a gene cluster with anothermember of the family, organic cation transporter like 4. Theencoded protein is a transmembrane protein involved in thetransport of small molecules. This protein can function to mediateurate uptake and is a high affinity nicotinate exchanger in thekidneys and the intestine.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Tzvetkov, M.V., et al. Clin. Pharmacol. Ther. 86(3):299-306(2009)Irshad, S., et al. Cell Death Differ. 16(6):890-898(2009)Bahn, A., et al. J. Biol. Chem. 283(24):16332-16341(2008)Daigo, Y., et al. DNA Res. 6(1):37-44(1999)
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