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TIA1 Antibody (Center R184) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P31483
Clone Names 80821095
Peptide ID 80821095
Additional Information
Gene ID 7072
Other Names Nucleolysin TIA-1 isoform p40, RNA-binding protein TIA-1, T-cell-restricted intracellular antigen-1, TIA-1, p40-TIA-1, TIA1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1830c was selected from the Center region of human TIA1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TIA1
Function Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
Cellular Location Cytoplasmic granule. Nucleus. Note=Accumulates in cytoplasmic stress granules (SG) following cellular damage
Research Areas
Citations (0)

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TIA1 is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.


Yeowell,H.N., Walker,L.C. J. Invest. Dermatol. 129 (6), 1402-1411 (2009)Eisinger-Mathason,T.S. Mol. Cell 31 (5), 722-736 (2008)Tang,H., Huang,Y. Intervirology 51 (3), 203-209 (2008)Dember,L.M., Kim,N.D. J. Biol. Chem. 271 (5), 2783-2788 (1996)

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$ 80.00
Cat# BP1830c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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