|Other Names||Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R, GNRHR, GRHR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Pituitary, ovary, testis, breast and prostate but not in liver and spleen|
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This gene encodes the receptor for type 1gonadotropin-releasing hormone. This receptor is a member of theseven-transmembrane, G-protein coupled receptor (GPCR) family. Itis expressed on the surface of pituitary gonadotrope cells as wellas lymphocytes, breast, ovary, and prostate. Following binding ofgonadotropin-releasing hormone, the receptor associates withG-proteins that activate a phosphatidylinositol-calcium secondmessenger system. Activation of the receptor ultimately causes therelease of gonadotropic luteinizing hormone (LH) and folliclestimulating hormone (FSH). Defects in this gene are a cause ofhypogonadotropic hypogonadism (HH). Alternative splicing results inmultiple transcript variants encoding different isoforms. More than18 transcription initiation sites in the 5' region and multiplepolyA signals in the 3' region have been identified for this gene.
Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Armstrong, S.P., et al. J. Biol. Chem. 285(32):24360-24371(2010)Lee, G., et al. Cancer Immunol. Immunother. 59(7):1011-1019(2010)Re, M., et al. PLoS ONE 5 (7), E11489 (2010) :Armstrong, S.P., et al. J. Biol. Chem. 284(51):35746-35757(2009)
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