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GNRHR Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P30968
Clone Names 81020130
Peptide ID 81020130
Additional Information
Gene ID 2798
Other Names Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R, GNRHR, GRHR
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms GRHR
Function Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Pituitary, ovary, testis, breast and prostate but not in liver and spleen
Research Areas
Citations (0)

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This gene encodes the receptor for type 1gonadotropin-releasing hormone. This receptor is a member of theseven-transmembrane, G-protein coupled receptor (GPCR) family. Itis expressed on the surface of pituitary gonadotrope cells as wellas lymphocytes, breast, ovary, and prostate. Following binding ofgonadotropin-releasing hormone, the receptor associates withG-proteins that activate a phosphatidylinositol-calcium secondmessenger system. Activation of the receptor ultimately causes therelease of gonadotropic luteinizing hormone (LH) and folliclestimulating hormone (FSH). Defects in this gene are a cause ofhypogonadotropic hypogonadism (HH). Alternative splicing results inmultiple transcript variants encoding different isoforms. More than18 transcription initiation sites in the 5' region and multiplepolyA signals in the 3' region have been identified for this gene.


Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Armstrong, S.P., et al. J. Biol. Chem. 285(32):24360-24371(2010)Lee, G., et al. Cancer Immunol. Immunother. 59(7):1011-1019(2010)Re, M., et al. PLoS ONE 5 (7), E11489 (2010) :Armstrong, S.P., et al. J. Biol. Chem. 284(51):35746-35757(2009)

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$ 80.00
Cat# BP18314a
Availability: In Stock
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