|Other Names||Osteopetrosis-associated transmembrane protein 1, Chloride channel 7 beta subunit, OSTM1, GL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for osteoclast and melanocyte maturation and function.|
|Cellular Location||Lysosome membrane; Single-pass type I membrane protein. Note=Requires CLCN7 to travel to lysosomes|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that may be involved in thedegradation of G proteins via the ubiquitin-dependent proteasomepathway. The encoded protein binds to members of subfamily A of theregulator of the G-protein signaling (RGS) family through anN-terminal leucine-rich region. This protein also has a centralRING finger-like domain and E3 ubiquitin ligase activity. Thisprotein is highly conserved from flies to humans. Defects in thisgene may cause the autosomal recessive, infantile malignant form ofosteopetrosis.
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Mazzolari, E., et al. Am. J. Hematol. 84(8):473-479(2009)Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)Feigin, M.E., et al. Cell. Signal. 20(5):949-957(2008)Maranda, B., et al. J. Bone Miner. Res. 23(2):296-300(2008)
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