|Other Names||Beta-1, 4 N-acetylgalactosaminyltransferase 1, (N-acetylneuraminyl)-galactosylglucosylceramide, GM2/GD2 synthase, GalNAc-T, B4GALNT1, GALGT, SIAT2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the biosynthesis of gangliosides GM2, GD2 and GA2.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
GM2 and GD2 gangliosides are sialic acid-containingglycosphingolipids. GalNAc-T is the enzyme involved in thebiosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-Tcatalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4linkage, resulting in the synthesis of G(M2) and G(D2),respectively.
Chen, L.C., et al. Lung Cancer 67(2):216-220(2010)Boraska, V., et al. Clin. Biochem. 42(9):819-822(2009)Gornati, R., et al. Mol. Cell. Biochem. 298 (1-2), 59-68 (2007) :Li, J., et al. J. Biol. Chem. 275(52):41476-41486(2000)Li, J., et al. J. Biol. Chem. 275(52):41476-41486(2000)
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