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B4GALNT1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q00973 |
|---|---|
| Clone Names | 110617070 |
| Gene ID | 2583 |
|---|---|
| Other Names | Beta-1, 4 N-acetylgalactosaminyltransferase 1, (N-acetylneuraminyl)-galactosylglucosylceramide, GM2/GD2 synthase, GalNAc-T, B4GALNT1, GALGT, SIAT2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | B4GALNT1 (HGNC:4117) |
|---|---|
| Synonyms | GALGT, SIAT2 |
| Function | Involved in the biosynthesis of gangliosides GM2, GD2, GT2 and GA2 from GM3, GD3, GT3 and GA3, respectively. |
| Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:Q10468}; Single-pass type II membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
GM2 and GD2 gangliosides are sialic acid-containingglycosphingolipids. GalNAc-T is the enzyme involved in thebiosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-Tcatalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4linkage, resulting in the synthesis of G(M2) and G(D2),respectively.
References
Chen, L.C., et al. Lung Cancer 67(2):216-220(2010)Boraska, V., et al. Clin. Biochem. 42(9):819-822(2009)Gornati, R., et al. Mol. Cell. Biochem. 298 (1-2), 59-68 (2007) :Li, J., et al. J. Biol. Chem. 275(52):41476-41486(2000)Li, J., et al. J. Biol. Chem. 275(52):41476-41486(2000)
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