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STAC Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q99469
Clone Names 110811229
Peptide ID 110811229
Additional Information
Other Names SH3 and cysteine-rich domain-containing protein, Src homology 3 and cysteine-rich domain-containing protein, STAC
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name STAC
Synonyms STAC1 {ECO:0000303|PubMed:29078335}
Function Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.
Cellular Location Cytoplasm, cytosol {ECO:0000250|UniProtKB:P97306}. Cell membrane {ECO:0000250|UniProtKB:P97306}; Peripheral membrane protein {ECO:0000250|UniProtKB:P97306}; Cytoplasmic side {ECO:0000250|UniProtKB:P97306}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P97306}; Peripheral membrane protein {ECO:0000250|UniProtKB:P97306}; Cytoplasmic side {ECO:0000250|UniProtKB:P97306} EMBL; D86640; BAA13152.1; -; mRNA EMBL; AK313493; BAG36275.1; -; mRNA EMBL; CH471055; EAW64474.1; -; Genomic_DNA CCDS; CCDS2662.1; - PIR; JC5270; JC5270 RefSeq; NP_003140.1; NM_003149.2 UniGene; Hs.56045; - PDB; 2DL4; NMR; -; A=288-342 PDB; 6B25; X-ray; 2.39 A; A=288-402 PDBsum; 2DL4; - PDBsum; 6B25; - ProteinModelPortal; Q99469; - SMR; Q99469; - BioGrid; 112646; 18 IntAct; Q99469; 18 MINT; Q99469; - STRING; 9606.ENSP00000273183; - TCDB; 8.A.34.1.2; the endophilin (endophilin) family iPTMnet; Q99469; - PhosphoSitePlus; Q99469; - BioMuta; STAC; - DMDM; 12229989; - PaxDb; Q99469; - PeptideAtlas; Q99469; - PRIDE; Q99469; - ProteomicsDB; 78285; - DNASU; 6769; - Ensembl; ENST00000273183; ENSP00000273183; ENSG00000144681 GeneID; 6769; - KEGG; hsa:6769; - UCSC; uc003cgh.2; human CTD; 6769; - DisGeNET; 6769; - EuPathDB; HostDB:ENSG00000144681.10; - GeneCards; STAC; - H-InvDB; HIX0119145; - HGNC; HGNC:11353; STAC HPA; HPA035143; - MIM; 602317; gene neXtProt; NX_Q99469; - OpenTargets; ENSG00000144681; - PharmGKB; PA36175; - eggNOG; ENOG410IF5B; Eukaryota eggNOG; ENOG410XQKX; LUCA GeneTree; ENSGT00390000008822; - HOGENOM; HOG000230980; - HOVERGEN; HBG017859; - InParanoid; Q99469; - OMA; PKGFRRY; - OrthoDB; EOG091G085P; - PhylomeDB; Q99469; - TreeFam; TF332878; - EvolutionaryTrace; Q99469; - GenomeRNAi; 6769; - PRO; PR:Q99469; - Proteomes; UP000005640; Chromosome 3 Bgee; ENSG00000144681; - CleanEx; HS_STAC; - ExpressionAtlas; Q99469; baseline and differential Genevisible; Q99469; HS GO; GO:0005829; C:cytosol; NAS:UniProtKB GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; ISS:UniProtKB GO; GO:0030315; C:T-tubule; IEA:Ensembl GO; GO:0044325; F:ion channel binding; IEA:Ensembl GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO; GO:0034605; P:cellular response to heat; IEA:Ensembl GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro GO; GO:0006936; P:muscle contraction; IEA:Ensembl GO; GO:2001259; P:positive regulation of cation channel activity; ISS:UniProtKB GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; ISS:UniProtKB GO; GO:1901387; P:positive regulation of voltage-gated calcium channel activity; ISS:UniProtKB GO; GO:0007165; P:signal transduction; NAS:UniProtKB CDD; cd00029; C1; 1 InterPro; IPR002219; PE/DAG-bd InterPro; IPR036028; SH3-like_dom_sf InterPro; IPR001452; SH3_domain InterPro; IPR035508; STAC1 PANTHER; PTHR15135:SF3; PTHR15135:SF3; 1 Pfam; PF00130; C1_1; 1 Pfam; PF00018; SH3_1; 1 PRINTS; PR00452; SH3DOMAIN SMART; SM00109; C1; 1 SMART; SM00326; SH3; 1 SUPFAM; SSF50044; SSF50044; 1 PROSITE; PS50002; SH3; 2 PROSITE; PS00479; ZF_DAG_PE_1; 1 PROSITE; PS50081; ZF_DAG_PE_2; 1 1: Evidence at protein level; 3D-structure; Cell membrane; Complete proteome; Cytoplasm; Membrane; Metal-binding; Polymorphism; Reference proteome; Repeat; SH3 domain; Zinc; Zinc-finger CHAIN 1 402 SH3 and cysteine-rich domain-containing protein /FTId=PRO_0000072235 DOMAIN 285 344 SH3 1. {ECO:0000255|PROSITE- ProRule:PRU00192} DOMAIN 347 402 SH3 2. {ECO:0000255|PROSITE- ProRule:PRU00192} ZN_FING 107 159 Phorbol-ester/DAG-type {ECO:0000255|PROSITE-ProRule:PRU00226} VARIANT 262 262 N -> S (in dbSNP:rs7634545) /FTId=VAR_034505 STRAND 289 294 {ECO:0000244|PDB:6B25} STRAND 311 316 {ECO:0000244|PDB:6B25} STRAND 319 327 {ECO:0000244|PDB:6B25} STRAND 330 335 {ECO:0000244|PDB:6B25} HELIX 336 338 {ECO:0000244|PDB:6B25} STRAND 339 341 {ECO:0000244|PDB:6B25} STRAND 347 353 {ECO:0000244|PDB:6B25} HELIX 359 361 {ECO:0000244|PDB:6B25} STRAND 371 374 {ECO:0000244|PDB:6B25} STRAND 382 387 {ECO:0000244|PDB:6B25} STRAND 390 395 {ECO:0000244|PDB:6B25} HELIX 396 398 {ECO:0000244|PDB:6B25} SEQUENCE 402 AA; 44554 MW; 211688D178E4F905 CRC64; MIPPSSPRED GVDGLPKEAV GAEQPPSPAS TSSQESKLQK LKRSLSFKTK SLRSKSADNF FQRTNSEDMK LQAHMVAEIS PSSSPLPAPG SLTSTPARAG LHPGGKAHAF QEYIFKKPTF CDVCNHMIVG TNAKHGLRCK ACKMSIHHKC TDGLAPQRCM GKLPKGFRRY YSSPLLIHEQ FGCIKEVMPI ACGNKVDPVY ETLRFGTSLA QRTKKGSSGS GSDSPHRTST SDLVEVPEEA NGPGGGYDLR KRSNSVFTYP ENGTDDFRDP AKNINHQGSL SKDPLQMNTY VALYKFVPQE NEDLEMRPGD IITLLEDSNE DWWKGKIQDR IGFFPANFVQ RLQQNEKIFR CVRTFIGCKE QGQITLKENQ ICVSSEEEQD GFIRVLSGKK KGLIPLDVLE NI
Research Areas
Citations (0)

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Background

STAC is probably involved in a neuron-specific signal transduction.

References

Petek, E., et al. Cytogenet. Cell Genet. 84 (3-4), 184-185 (1999) :Suzuki, H., et al. Biochem. Biophys. Res. Commun. 229(3):902-909(1996)

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Cat# BP18394b
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