|Other Names||Glutamate-rich WD repeat-containing protein 1, GRWD1, GRWD, KIAA1942, WDR28|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GRWD, KIAA1942, WDR28|
|Function||Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725).|
|Cellular Location||Nucleus, nucleolus. Nucleus. Chromosome. Note=Present in the nucleus throughout interphase and is detached from chromatin at the onset of mitosis and rebinds at telophase when the pre-replication complexes (pre-RC) is formed (PubMed:25990725)|
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Provided below are standard protocols that you may find useful for product applications.
GRWD1 is a component of the 50S and 80S preribosomalcomplexes and plays a role in ribosome biogenesis (Gratenstein etal., 2005 [PubMed 15885502]).
Higa, L.A., et al. Nat. Cell Biol. 8(11):1277-1283(2006)Gratenstein, K., et al. Genomics 85(6):762-773(2005)Trzcinska, A.M., et al. Mol. Biol. Rep. 29(4):347-352(2002)
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