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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   PPP4R2 Antibody (Center) Blocking Peptide   

PPP4R2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NY27
Clone Names 110726168
Peptide ID 110726168
Additional Information
Gene ID 151987
Other Names Serine/threonine-protein phosphatase 4 regulatory subunit 2, PPP4R2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP4R2
Function Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.

References

Lee, D.H., et al. Nat. Struct. Mol. Biol. 17(3):365-372(2010)Chen, G.I., et al. J. Biol. Chem. 283(43):29273-29284(2008)Chowdhury, D., et al. Mol. Cell 31(1):33-46(2008)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Gingras, A.C., et al. Mol. Cell Proteomics 4(11):1725-1740(2005)

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$ 80.00
Cat# BP18485c
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