|Other Names||Peptidoglycan recognition protein 4, Peptidoglycan recognition protein I-beta, PGLYRPIbeta, PGRP-I-beta, Peptidoglycan recognition protein intermediate beta, PGLYRP4, PGRPIB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity.|
|Tissue Location||Detected in skin epidermis, eccrine sweat glands and ducts, mucous cells in the submandibular salivary gland, mucous cells in the throat, ciliary body epithelial cells of the eye, small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). High expression in skin and esophagus. Expressed also to a much lesser extent in the tonsils and thymus.|
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Provided below are standard protocols that you may find useful for product applications.
Peptidoglycan recognition proteins, such as PGRPI-beta,are part of the innate immune system and recognize peptidoglycan, aubiquitous component of bacterial cell walls.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Cho, S., et al. Proc. Natl. Acad. Sci. U.S.A. 104(21):8761-8766(2007)Lu, X., et al. J. Biol. Chem. 281(9):5895-5907(2006)Sun, C., et al. Hum. Genet. 119 (1-2), 113-125 (2006) :
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