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SHARPIN Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9H0F6
Clone Names 110811208
Peptide ID 110811208
Additional Information
Gene ID 81858
Other Names Sharpin, Shank-associated RH domain-interacting protein, Shank-interacting protein-like 1, hSIPL1, SHARPIN, SIPL1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms SIPL1
Function Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
Cellular Location Cytoplasm, cytosol. Cell junction, synapse. Note=Enriched at synaptic sites in mature neurons where it colocalizes with SHANK1.
Tissue Location Highly expressed in skeletal muscle and placenta and at lower levels in brain, heart, colon without mucosa, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes. Up-regulated in various tumor tissues such as kidney, liver, ovary and pancreas tumors
Research Areas
Citations (0)

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SHARPIN may have a role in normal immune development and control of inflammation (By similarity).


Jung, J., et al. Mol. Cell. Biochem. 340 (1-2), 161-167 (2010) :Vega, A., et al. Gynecol. Oncol. 112(1):210-214(2009)Daigo, Y., et al. J. Gastroenterol. Hepatol. 18(6):712-718(2003)Lim, S., et al. Mol. Cell. Neurosci. 17(2):385-397(2001)

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$ 80.00
Cat# BP18513c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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