|Other Names||Sharpin, Shank-associated RH domain-interacting protein, Shank-interacting protein-like 1, hSIPL1, SHARPIN, SIPL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.|
|Cellular Location||Cytoplasm, cytosol. Cell junction, synapse. Note=Enriched at synaptic sites in mature neurons where it colocalizes with SHANK1.|
|Tissue Location||Highly expressed in skeletal muscle and placenta and at lower levels in brain, heart, colon without mucosa, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes. Up-regulated in various tumor tissues such as kidney, liver, ovary and pancreas tumors|
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Provided below are standard protocols that you may find useful for product applications.
SHARPIN may have a role in normal immune development and control of inflammation (By similarity).
Jung, J., et al. Mol. Cell. Biochem. 340 (1-2), 161-167 (2010) :Vega, A., et al. Gynecol. Oncol. 112(1):210-214(2009)Daigo, Y., et al. J. Gastroenterol. Hepatol. 18(6):712-718(2003)Lim, S., et al. Mol. Cell. Neurosci. 17(2):385-397(2001)
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