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PI3KC3 Antibody (S851) Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP1851j | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
PI3KC3 Antibody (S851) Blocking Peptide - Product info | |
| Primary Accession | Q8NEB9 |
| Clone Names | 70226222 |
| Calculated MW | 101549 Da |
PI3KC3 Antibody (S851) Blocking Peptide - Additional info | |
| Gene ID 5289 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP1851j was selected from the S851 region of human PI3KC3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
PI3KC3 Antibody (S851) Blocking Peptide - Protein Information | |
| Name PIK3C3 | |
| Synonyms VPS34 | |
| Function Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes Required for the abcission step in cytokinesis. Required for transport from early to late endosomes | |
| Cellular Location Midbody. Late endosome. | |
| Tissue Location Ubiquitously expressed, with a highest expression in skeletal muscle | |
PI3KC3 Antibody (S851) Blocking Peptide - Related products
AP1851a: PI3KC3 Antibody (N-term G24)
AP1851b: PI3KC3 Antibody (C-term E785)
AP1851c: PI3KC3 Antibody (Center K269)
AP1851d: PI3KC3 Antibody (Center E501)
AP1851e: PI3KC3 Antibody (S34)
AP1851g: PI3KC3 Antibody (S164)
AP1851h: PI3KC3 Antibody (S425)
AP1851j: PI3KC3 Antibody (S851)
AP3368a: Phospho-PI3KC3-S282 Antibody
AP3369a: Phospho-PI3KC3-S676 Antibody
AP3399a: Phospho-PI3KC3-S164 Antibody
AP8014a: PI3KC3 Antibody (N-term)
RI13993: PIK3C3 predesign siRNA
BP1851a: Kinase PI3KC3 Antibody (N-term) Blocking Peptide
BP1851b: Kinase PI3KC3 Antibody (C-term) Blocking Peptide
BP1851c: Kinase PI3KC3 Antibody (Center K269) Blocking Peptide
BP1851e: PI3KC3 Antibody (S34) Blocking Peptide
BP1851g: PI3KC3 Antibody (S164) Blocking Peptide
BP1851h: PI3KC3 Antibody (S425) Blocking Peptide
BP1851j: PI3KC3 Antibody (S851) Blocking Peptide
BP3368a: Phospho-PI3KC3-S282 Antibody Blocking Peptide
BP3369a: Phospho-PI3KC3-S676 Antibody Blocking Peptide
PI3KC3 Antibody (S851) Blocking Peptide - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate.Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway.
REFERENCES
Vergne, I., et al., J. Exp. Med. 198(4):653-659 (2003).Volinia, S., et al., EMBO J. 14(14):3339-3348 (1995).
