|Other Names||Cadherin-11, OSF-4, Osteoblast cadherin, OB-cadherin, CDH11|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a type II classical cadherin from thecadherin superfamily, integral membrane proteins that mediatecalcium-dependent cell-cell adhesion. Mature cadherin proteins arecomposed of a large N-terminal extracellular domain, a singlemembrane-spanning domain, and a small, highly conserved C-terminalcytoplasmic domain. Type II (atypical) cadherins are defined basedon their lack of a HAV cell adhesion recognition sequence specificto type I cadherins. Expression of this particular cadherin inosteoblastic cell lines, and its upregulation duringdifferentiation, suggests a specific function in bone developmentand maintenance.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Sachdeva, M., et al. Cancer Res. 70(1):378-387(2010)Canova, C., et al. Cancer Res. 69(7):2956-2965(2009)Farina, A.K., et al. PLoS ONE 4 (3), E4797 (2009) :Brieger, J., et al. APMIS 116(12):1050-1057(2008)
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