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CDH11 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P55287 |
|---|---|
| Clone Names | 70730036 |
| Gene ID | 1009 |
|---|---|
| Other Names | Cadherin-11, OSF-4, Osteoblast cadherin, OB-cadherin, CDH11 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CDH11 |
|---|---|
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed:33811546). Involved in the regulation of cell migration (PubMed:33811546). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. In the embryo from 67 to 72 days of gestation, detected at high levels in facial mesenchyme including the central palatal mesenchyme, dental mesenchyme, the eye and optic muscle, and the tongue (at protein level) (PubMed:33811546) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a type II classical cadherin from thecadherin superfamily, integral membrane proteins that mediatecalcium-dependent cell-cell adhesion. Mature cadherin proteins arecomposed of a large N-terminal extracellular domain, a singlemembrane-spanning domain, and a small, highly conserved C-terminalcytoplasmic domain. Type II (atypical) cadherins are defined basedon their lack of a HAV cell adhesion recognition sequence specificto type I cadherins. Expression of this particular cadherin inosteoblastic cell lines, and its upregulation duringdifferentiation, suggests a specific function in bone developmentand maintenance.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Sachdeva, M., et al. Cancer Res. 70(1):378-387(2010)Canova, C., et al. Cancer Res. 69(7):2956-2965(2009)Farina, A.K., et al. PLoS ONE 4 (3), E4797 (2009) :Brieger, J., et al. APMIS 116(12):1050-1057(2008)
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